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CS-W001157 4
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7-Chloroquinoline-2-carbaldehyde

  • CAS No. 59394-27-3

  • Cat. No. CS-0187266
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Chloroquinoline-2-carbaldehyde|CS-0187266

Structure of 59394-27-3

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General Information

  • CAS No. 59394-27-3
  • Cat. No. CS-0187266
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆ClNO
  • Molecular Weight 191.61
  • Synonym(s) 7-chloroquinoline-2-carboxaldehyde
  • SMILES C1=C2C=CC(=NC2=CC(=C1)Cl)C=O

Description

7-Chloroquinoline-2-carbaldehyde delivers a potent electron-deficient scaffold for synthetic and medicinal chemistry applications. This bench-stable aldehyde integrates readily into conjugate addition and condensation reactions, enabling efficient access to functionalized quinoline derivatives under standard conditions.

Application

7-Chloroquinoline-2-carbaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of quinoline-based scaffolds. Its aldehyde functionality facilitates nucleophilic addition, reductive amination, and condensation reactions, while the chloro substituent offers orthogonal reactivity for further functionalization. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for medicinal chemistry campaigns and process development.

Synthesis

  • Route1

    References

    • Barbier, Christine; Joissains, Arnaud; Commercon, Alain; Riou, Jean-Francois; Huet, Francois Heterocycles, 2000 , vol. 53, # 1 p. 37 - 48

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.7007
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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