Lot numbers can be found on the outside label of a product:
8-Chloro-2-methylquinoline
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CAS No. 3033-82-7
- Cat. No. CS-0106374
- Purity≥98%
- MDL No.MFCD00051764
*For research and further manufacturing use only, not for direct human use.
Structure of 3033-82-7
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General Information
- CAS No. 3033-82-7
- Cat. No. CS-0106374
- Purity ≥98%
- MDL No. MFCD00051764
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₈ClN
- Molecular Weight 177.63
- Synonym(s) 8-CHLOROQUINALDINE
- SMILES CC1=NC2=C(Cl)C=CC=C2C=C1
Description
8-Chloro-2-methylquinoline is a heterocyclic compound featuring a quinoline core substituted with chlorine at the 8-position and a methyl group at the 2-position. This electron-deficient scaffold integrates readily into transition metal-catalyzed coupling reactions, serving as a robust ligand precursor in catalytic systems. The steric and electronic profile enhances stability under standard reaction conditions.
Application
8-Chloro-2-methylquinoline serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds through standard functional group transformations. Its chlorine and methyl substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and electrophilic substitution, enhancing synthetic flexibility. Bench-stable and readily purified, it functions effectively in multi-step synthesis of bioactive molecules, particularly in kinase inhibitor and antimalarial research.
Synthesis
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Route1
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123-73-9 -
95-51-2
- ~86%
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In-stock
3033-82-7
References
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Sivaprasad, Ganesabaskaran; Rajesh, Rengasamy; Perumal, Paramasivan T. Tetrahedron Letters, 2006 , vol. 47, # 11 p. 1783 - 1785
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Route2
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64-17-5
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95-51-2
- ~64%
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In-stock
3033-82-7
References
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Khusnutdinov; Bayguzina; Aminov Russian Chemical Bulletin, 2013 , vol. 62, # 1 p. 133 - 137 Izv. Akad. Nauk, Ser. Khim., 2013 , # 1 p. 134 - 138
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Route3
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95-51-2
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123-73-9
- ~%
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In-stock
3033-82-7
References
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DE567273 , ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 3.19662
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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