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CS-W001157 4
Total: USD 88.00

4-Bromobenzoic hydrazide

  • CAS No. 5933-32-4

  • Cat. No. CS-0130435
  • Purity≥98%
  • MDL No.MFCD00007602

*For research and further manufacturing use only, not for direct human use.

4-Bromobenzoic hydrazide|CS-0130435

Structure of 5933-32-4

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General Information

  • CAS No. 5933-32-4
  • Cat. No. CS-0130435
  • Purity ≥98%
  • MDL No. MFCD00007602
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrN₂O
  • Molecular Weight 215.05
  • Synonym(s) 4-Bromobenzoylhydrazine
  • SMILES O=C(C1=CC=C(C=C1)Br)NN

Description

4-Bromobenzoic hydrazide has been used in the preparation of:{2-[1-oxo-3-(4-bromophenyl)-2-propenyl]hydrazide}-4-bromobenzoic acid{2,2-[1,4-phenylenebis(1-oxo-2-propene-3,1-diyl)]dihydrazide}-p-bromobenzoic acidsubstituted pyrido[1,2-a]pyrimidine-2,4(3H)-diones (PPMDO)

Application

4-Bromobenzoic hydrazide serves as a versatile building block for the synthesis of heterocyclic scaffolds, particularly in the construction of benzimidazoles and pyrazoles via cyclization reactions. Its bromo group enables subsequent cross-coupling transformations, while the hydrazide functionality facilitates condensation with carbonyl compounds under mild conditions. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for iterative medicinal chemistry campaigns and process-scale applications.

Synthesis

  • Route1

    References

    • SEMICONDUCTOR ENERGY LABORATORY CO., LTD. Patent: WO2009/81718 A1, 2009 ; Location in patent: Page/Page column 107-108 ;
  • Route2

    References

    • ARES TRADING S.A.; QUATTROPANI, Anna; SWINNEN, Dominique Patent: WO2013/182274 A1, 2013 ; Location in patent: Page/Page column 55; 56 ;
  • Route3

    References

    • Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 181, # 9 p. 2079 - 2087

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   1.0526
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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