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CS-W001157 4
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Pyrazinoic acid hydrazide

  • CAS No. 768-05-8

  • Cat. No. CS-W003922
  • Purity≥97%
  • MDL No.MFCD00778762

*For research and further manufacturing use only, not for direct human use.

Pyrazinoic acid hydrazide|CS-W003922

Structure of 768-05-8

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General Information

  • CAS No. 768-05-8
  • Cat. No. CS-W003922
  • Purity ≥97%
  • MDL No. MFCD00778762
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₄O
  • Molecular Weight 138.13
  • Synonym(s) Pyrazine-2-carbohydrazide
  • SMILES NNC(=O)c1cnccn1

Description

Pyrazinoic acid hydrazide integrates a hydrazide functional group onto a pyrazine core, offering enhanced reactivity in bioconjugation and heterocyclic synthesis. This bench-stable derivative enables efficient coupling strategies under mild conditions, facilitating the construction of complex nitrogen-rich architectures in medicinal chemistry and materials science applications.

Application

Pyrazinoic acid hydrazide serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrazine-based scaffolds through condensation and cyclization reactions. Its hydrazide functionality facilitates robust coupling with carbonyl compounds and offers good bench stability, simplifying handling and purification. This compound functions effectively in the construction of bioactive heterocycles relevant to medicinal chemistry research, particularly in the development of antimicrobial agents and kinase inhibitors.

Synthesis

  • Route1

    References

    • WO2005/16909 A1, ; Page/Page column 73 ; WO 2005/016909 A1
  • Route2

    References

    • European Journal of Medicinal Chemistry, , vol. 47, # 1 p. 452 - 461
  • Route3
    • Pyrazine-2-carboxylic acid Bortezomib Impurity|CS-0169692
      98-97-5
    • ~%
    • In-stock
      Pyrazinoic acid hydrazide|CS-W003922
      768-05-8

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 3 p. 817 - 821

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   80.9
  • LogP   -0.9199
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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