2-Chloro-5-methylpyrazine

Name: 2-Chloro-5-methylpyrazine
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CAS No. 59303-10-5
Cat. No. CS-W009243
Purity≥96%
MDL No.MFCD00055039

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 59303-10-5
Cat. No. CS-W009243
Purity ≥96%
MDL No. MFCD00055039
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂
Molecular Weight 128.56
Synonym(s) 5-Chloro-2-methylpyrazine; pyrazine, 2-chloro-5-methyl-
SMILES CC1=CN=C(Cl)C=N1

Description

2-Chloro-5-methylpyrazine is a heterocyclic compound featuring a chlorinated pyrazine core with a methyl substituent at the 5-position. This electron-deficient scaffold integrates readily into synthetic routes for pharmaceutical intermediates and agrochemicals. The molecule exhibits enhanced reactivity in nucleophilic substitution processes due to the combined influence of the chlorine and electron-withdrawing nitrogen atoms. Its bench-stable nature supports reliable handling under standard conditions.

Application

2-Chloro-5-methylpyrazine serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its electrophilic chlorine atom enables palladium-catalyzed cross-coupling reactions, while the methyl group provides a handle for further functionalization. The pyrazine core offers favorable metabolic stability and π-electron density, enhancing its utility in constructing complex pharmaceutical scaffolds. This compound exhibits excellent bench stability and compatibility with standard purification techniques.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 1.43842
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2-Chloro-5-methylpyrazine

CAS No. 59303-10-5

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