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CS-W001157 4
Total: USD 88.00

1-Bromo-4-(difluoromethoxy)benzene

  • CAS No. 5905-69-1

  • Cat. No. CS-W013106
  • Purity≥98%
  • MDL No.MFCD00221465

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4-(difluoromethoxy)benzene|CS-W013106

Structure of 5905-69-1

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General Information

  • CAS No. 5905-69-1
  • Cat. No. CS-W013106
  • Purity ≥98%
  • MDL No. MFCD00221465
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrF₂O
  • Molecular Weight 223.02
  • Synonym(s) 4-(DIFLUOROMETHOXY)BROMOBENZENE
  • SMILES C1=CC(=CC=C1OC(F)F)Br

Description

1-Bromo-4-(difluoromethoxy)benzene features a para-substituted aryl bromide with a difluoromethoxy group enhancing electron-withdrawal and metabolic stability. This bench-stable, moisture-tolerant reagent integrates readily into cross-coupling reactions, enabling efficient access to fluorinated aromatic scaffolds for medicinal chemistry and materials science applications.

Application

1-Bromo-4-(difluoromethoxy)benzene serves as a versatile aryl halide building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl architectures. The difluoromethoxy group imparts enhanced metabolic stability and modulates electronic properties, making this compound valuable in medicinal chemistry and agrochemical research. Bench-stable and compatible with standard reaction conditions, it facilitates straightforward functionalization and purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   3.0505
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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