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CS-W001157 4
Total: USD 88.00

1-Bromo-3-(difluoromethoxy)benzene

  • CAS No. 262587-05-3

  • Cat. No. CS-W007939
  • Purity≥98%
  • MDL No.MFCD00236233

*For research and further manufacturing use only, not for direct human use.

1-Bromo-3-(difluoromethoxy)benzene|CS-W007939

Structure of 262587-05-3

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General Information

  • CAS No. 262587-05-3
  • Cat. No. CS-W007939
  • Purity ≥98%
  • MDL No. MFCD00236233
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrF₂O
  • Molecular Weight 223.02
  • Synonym(s) 3-Bromophenyl difluoromethyl ether
  • SMILES FC(F)OC1=CC(Br)=CC=C1

Description

1-Bromo-3-(difluoromethoxy)benzene features a strategically positioned difluoromethoxy group that enhances metabolic stability and modulates lipophilicity. This aryl bromide integrates readily into cross-coupling reactions, enabling efficient access to complex fluorinated aromatic scaffolds under standard conditions.

Application

1-Bromo-3-(difluoromethoxy)benzene serves as a versatile aryl halide building block for palladium-catalyzed cross-coupling reactions, including Suzuki, Stille, and Negishi couplings. The difluoromethoxy group imparts enhanced metabolic stability and modulates electronic properties, making this compound valuable in the synthesis of fluorinated aromatic scaffolds relevant to medicinal chemistry and agrochemical research. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient, scalable transformations.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   3.0505
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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