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Structure of 175278-33-8
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1-Bromo-2-(difluoromethoxy)benzene features a strategically positioned difluoromethoxy group that enhances electron-withdrawal and metabolic stability. This ortho-brominated aryl difluoromethyl ether serves as a key building block for pharmaceutical intermediates, enabling efficient coupling reactions under standard conditions. Its bench-stable nature supports reliable handling in synthetic workflows.
1-Bromo-2-(difluoromethoxy)benzene serves as a versatile aryl halide building block for palladium-catalyzed cross-coupling reactions, including Suzuki, Stille, and Negishi couplings. The difluoromethoxy group imparts enhanced metabolic stability and modulates electronic properties, making this compound valuable in medicinal chemistry. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex biaryl architectures.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: