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CS-W001157 4
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(S)-2-Aminobutan-1-ol

  • CAS No. 5856-62-2

  • Cat. No. CS-W013745
  • Purity≥98%
  • MDL No.MFCD00064418

*For research and further manufacturing use only, not for direct human use.

(S)-2-Aminobutan-1-ol|CS-W013745

Structure of 5856-62-2

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General Information

  • CAS No. 5856-62-2
  • Cat. No. CS-W013745
  • Purity ≥98%
  • MDL No. MFCD00064418
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₁NO
  • Molecular Weight 89.14
  • Synonym(s) S-(+)-2-Amino-1-butanol
  • SMILES CC[C@H](N)CO

Description

(S)-(+)-2-Amino-1-butanol is a chiral amino alcohol that may be used in the synthesis of (S)-2-(6-benzylamino-9-isopropyl-9H-purin-2-ylamino) butan-1-ol, an (S)-enantiomer of roscovitine. It can also be used to synthesize homochiral 2-methylpyrroles. (S)-(+)-2-Amino-1-butanol is an intermediate for the synthesis of (S,S)-ethambutol, an antibacterial agent for treating tuberculosis.

Application

(S)-2-Aminobutan-1-ol serves as a valuable chiral building block in medicinal chemistry, enabling stereoselective synthesis of bioactive molecules. Its primary amine and hydroxyl groups offer orthogonal reactivity for diverse functionalization, while the (S)-configuration ensures enantiomeric purity critical for drug development. The compound exhibits good bench stability and compatibility with standard protection/deprotection strategies, facilitating efficient incorporation into complex scaffolds such as β-amino alcohols and heterocyclic intermediates.

Synthesis

  • Route1
    • null|null
      157985-09-6
    • ~84%
    • In-stock
      (S)-2-Aminobutan-1-ol|CS-W013745
      5856-62-2

    References

    • Segat-Dioury, Fabienne; Lingibe, Olivier; Graffe, Bernadette; Sacquet, Marie-Claude; Lhommet, Gerard Tetrahedron, 2000 , vol. 56, # 2 p. 233 - 248
  • Route2
    • null|null
      83053-82-1
    • ~93%
    • In-stock
      (S)-2-Aminobutan-1-ol|CS-W013745
      5856-62-2

    References

    • Trost, Barry M.; Bunt, Richard C.; Lemoine, Remy C.; Calkins, Trevor L. Journal of the American Chemical Society, 2000 , vol. 122, # 25 p. 5968 - 5976
  • Route3
    • null|null
      34114-57-3
    • ~70%
    • In-stock
      (S)-2-Aminobutan-1-ol|CS-W013745
      5856-62-2

    References

    • Fadnavis; Sharfuddin, Mohd.; Vadivel Tetrahedron Asymmetry, 1999 , vol. 10, # 23 p. 4495 - 4500

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.284
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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