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CS-W001157 4
Total: USD 88.00

2-(Aminomethyl)quinoline

  • CAS No. 5760-20-3

  • Cat. No. CS-0084595
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Aminomethyl)quinoline|CS-0084595

Structure of 5760-20-3

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General Information

  • CAS No. 5760-20-3
  • Cat. No. CS-0084595
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂
  • Molecular Weight 158.20
  • Synonym(s) Quinolin-2-ylmethanamine
  • SMILES NCC1=NC2=CC=CC=C2C=C1

Description

2-(Aminomethyl)quinoline serves as a pivotal scaffold in medicinal chemistry, integrating a flexible amine handle with a rigid quinoline core. This combination enables efficient conjugation and metal coordination, supporting applications in catalyst design and bioactive molecule synthesis. The compound exhibits favorable solubility and stability under standard conditions, facilitating use in multistep transformations and functional group interconversions.

Application

2-(Aminomethyl)quinoline serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically active heterocycles. Its pendant primary amine facilitates straightforward derivatization via amidation, alkylation, and reductive amination, while the quinoline core provides robust structural rigidity and π-stacking capability. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for high-throughput synthesis and lead optimization campaigns.

Synthesis

  • Route1

    References

    • Quinn, Jordan R.; Zimmerman, Steven C. Journal of Organic Chemistry, 2005 , vol. 70, # 19 p. 7459 - 7467
  • Route2
    • Quinolin-2-ylmethanamine;dihydrochloride|CS-0060584
      18004-62-1
    • ~83%
    • In-stock
      2-(Aminomethyl)quinoline|CS-0084595
      5760-20-3

    References

    • Maj, Anna M.; Suisse, Isabelle; Hardouin, Christophe; Agbossou-Niedercorn, Francine Tetrahedron, 2013 , vol. 69, # 44 p. 9322 - 9328
  • Route3
    • null|null
      1131-68-6
    • ~73%
    • In-stock
      2-(Aminomethyl)quinoline|CS-0084595
      5760-20-3

    References

    • Sahu, Rojalin; Padhi, Sumanta Kumar; Jena, Himanshu Sekhar; Manivannan, Vadivelu Inorganica Chimica Acta, 2010 , vol. 363, # 7 p. 1448 - 1454

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.6935
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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