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CS-W001157 4
Total: USD 88.00

4,6-Dichloro-N,N-dimethylpyrimidin-2-amine

  • CAS No. 5734-68-9

  • Cat. No. CS-0046953
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloro-N,N-dimethylpyrimidin-2-amine|CS-0046953

Structure of 5734-68-9

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General Information

  • CAS No. 5734-68-9
  • Cat. No. CS-0046953
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇Cl₂N₃
  • Molecular Weight 192.05
  • Synonym(s) 4,6-DICHLORO-N,N-DIMETHYL-2-PYRIMIDINAMINE
  • SMILES ClC1=NC(N(C)C)=NC(Cl)=C1

Description

4,6-Dichloro-N,N-dimethylpyrimidin-2-amine features a pyrimidine core bearing two chlorine substituents at the 4 and 6 positions and a dimethylamino group at C2. This electron-deficient heterocycle serves as a potent electrophilic coupling partner in nucleophilic substitution reactions. The molecule exhibits excellent stability under standard conditions and facilitates efficient functionalization in synthetic workflows involving amine or thiol nucleophiles.

Application

4,6-Dichloro-N,N-dimethylpyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of substituted pyrimidine scaffolds. Its dual chlorine substituents facilitate nucleophilic aromatic substitution under mild conditions, while the dimethylamino group enhances solubility and reactivity. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis and functional group interconversions in API development workflows.

Synthesis

  • Route1

    References

    • European Journal of Organic Chemistry, , # 24 p. 4117 - 4122
  • Route2
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      117290-56-9
    • ~%
    • In-stock
      4,6-Dichloro-N,N-dimethylpyrimidin-2-amine|CS-0046953
      5734-68-9

    References

    • Journal of the Chemical Society, , p. 1532 Journal of the Chemical Society, , p. 2146,2151
  • Route3
    • In-stock
      NSC 6494|CS-W008766
      3764-01-0
    • null|null
      124-40-3
    • ~%
    • In-stock
      4,6-Dichloro-N,N-dimethylpyrimidin-2-amine|CS-0046953
      5734-68-9

    References

    • Journal of the Chemical Society, , p. 1532 Journal of the Chemical Society, , p. 2146,2151 Journal of the Chemical Society, , p. 726,731

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.02
  • LogP   1.8494
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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