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CS-W001157 4
Total: USD 88.00

1-(Cyclopropylmethyl)piperazine

  • CAS No. 57184-25-5

  • Cat. No. CS-0011260
  • Molecule weight140.23
  • Purity≥96%
  • MDL No.MFCD00872053

*For research and further manufacturing use only, not for direct human use.

1-(Cyclopropylmethyl)piperazine|CS-0011260

Structure of 57184-25-5

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General Information

  • CAS No. 57184-25-5
  • Cat. No. CS-0011260
  • Purity ≥96%
  • MDL No. MFCD00872053
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆N₂
  • Molecular Weight 140.23
  • Synonym(s) 4-(Cyclopropylmethyl)piperazine; N-(Cyclopropylmethyl)piperazine; 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97
  • SMILES N1(CC2CC2)CCNCC1

Description

1-(Cyclopropylmethyl)piperazine is a sterically hindered piperazine derivative featuring a cyclopropylmethyl group that enhances lipophilicity and metabolic stability. This scaffold integrates readily into bioactive molecules, offering improved membrane permeability and solubility in medicinal chemistry applications.

Application

1-(Cyclopropylmethyl)piperazine serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard amine functionalization and coupling reactions. Its cyclopropylmethyl substituent enhances metabolic stability and modulates lipophilicity, while the piperazine core offers favorable solubility and hydrogen-bonding capacity. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, facilitating efficient synthesis of target molecules in multi-step routes.

Synthesis

  • Route1
    • 1-Piperazinecarboxylic acid, 4-(cyclopropylmethyl)-, 1,1-dimethylethyl ester|CS-0011259
      373608-50-5
    • ~%
    • In-stock
      1-(Cyclopropylmethyl)piperazine|CS-0011260
      57184-25-5

    References

    • Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2833 - 2838
  • Route2

    References

    • EP1508570 A1, ; Page/Page column 134 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P280-P305+P351+P338-P310

Quality Control

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.3016
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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