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CS-W001157 4
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3-Aminosalicylic acid

  • CAS No. 570-23-0

  • Cat. No. CS-0356699
  • Purity≥98%
  • MDL No.MFCD00010299

*For research and further manufacturing use only, not for direct human use.

3-Aminosalicylic acid|CS-0356699

Structure of 570-23-0

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General Information

  • CAS No. 570-23-0
  • Cat. No. CS-0356699
  • Purity ≥98%
  • MDL No. MFCD00010299
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 3-ASA
  • SMILES O=C(C1=C(O)C(N)=CC=C1)O

Description

3-Aminosalicylic acid is a building block that can be used to synthesize antimycin A3. It can also be used to synthesize 2-alkoxy-3-(arylaminomethylene)chroman-4-ones and 3-(aryliminomethyl)chromones by reacting with 3-formylchromones.

Application

3-Aminosalicylic acid serves as a key building block in the synthesis of pharmaceutical intermediates and heterocyclic scaffolds. Its ortho-dihydroxy and primary amine functionalities enable diverse transformations, including metal-catalyzed couplings, electrophilic substitutions, and coordination chemistry. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Anilinokr. Promysl., , vol. 3, p. 391,397, 400 Chem. Zentralbl., , vol. 106, # I p. 226
  • Route2

    References

    • RSC Advances, , vol. 4, # 19 p. 9673 - 9679
  • Route3
    • null|null
      642-82-0
    • ~%
    • In-stock
      3-Aminosalicylic acid|CS-0356699
      570-23-0

    References

    • Journal of the American Chemical Society, , vol. 75, p. 3623

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   83.55
  • LogP   0.6726
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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