2,4-Dichloro-5-methylthieno[2,3-d]pyrimidine

Name: 2,4-Dichloro-5-methylthieno[2,3-d]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 56844-38-3
Cat. No. CS-0052162
Purity≥97%
MDL No.MFCD09965519

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-5-methylthieno[2,3-d]pyrimidine|CS-0052162

Structure of 56844-38-3

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 56844-38-3
Cat. No. CS-0052162
Purity ≥97%
MDL No. MFCD09965519
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄Cl₂N₂S
Molecular Weight 219.10
Synonym(s) 2,4-DICHLORO-5-METHYL-THIENO[2,3-D]PYRIMIDINE
SMILES CC1=CSC2=NC(Cl)=NC(Cl)=C12

Description

2,4-Dichloro-5-methylthieno[2,3-d]pyrimidine features a fused thienopyrimidine core with strategically positioned chloro and methyl substituents, delivering enhanced reactivity in cross-coupling transformations. This electron-deficient scaffold integrates readily into advanced heterocyclic architectures, enabling efficient access to functionalized pyrimidine derivatives under standard conditions.

Application

2,4-Dichloro-5-methylthieno[2,3-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of purine and pyrimidine-based heterocycles. Its dichloro substitution pattern facilitates nucleophilic displacement reactions, while the methylthienopyrimidine core provides structural rigidity and favorable electronic properties. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, supporting scalable synthesis of kinase inhibitors and other bioactive scaffolds.

Synthesis

Route1
- In-stock
  
  4623-55-6
- 503-38-8
- ~50%
- In-stock
  
  56844-38-3
References
- Roecker, Anthony J.; Mercer, Swati P.; Harrell, C. Meacham; Garson, Susan L.; Fox, Steven V.; Gotter, Anthony L.; Prueksaritanont, Thomayant; Cabalu, Tamara D.; Cui, Donghui; Lemaire, Wei; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 9 p. 2079 - 2085
Route2
- 75860-79-6
- ~30%
- In-stock
  
  56844-38-3
References
- Deng, Jifeng; Peng, Li; Zhang, Guicheng; Lan, Xiaobing; Li, Chufang; Chen, Fuxin; Zhou, Yayao; Lin, Zuoxian; Chen, Ling; Dai, Renke; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Hu, Wenhui European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 71 - 76

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 25.78
LogP 3.30652
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Key Words

56844-38-3 sigma56844-38-3 manufacturer56844-38-3 price56844-38-3 structure56844-38-3 SDSbuy 56844-38-356844-38-3 supplier56844-38-3 uses56844-38-3 molecular weightprice of 56844-38-356844-38-3 chemical name formula of 56844-38-3

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2,4-Dichloro-5-methylthieno[2,3-d]pyrimidine

CAS No. 56844-38-3

Recommended Products