4-Chloro-5-methylthieno[2,3-d]pyrimidine

Name: 4-Chloro-5-methylthieno[2,3-d]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 43088-67-1
Cat. No. CS-0042908
Purity≥98%
MDL No.MFCD00205201

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-5-methylthieno[2,3-d]pyrimidine|CS-0042908

Structure of 43088-67-1

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General Information

CAS No. 43088-67-1
Cat. No. CS-0042908
Purity ≥98%
MDL No. MFCD00205201
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClN₂S
Molecular Weight 184.65
Synonym(s) None
SMILES CC1=CSC2=C1C(Cl)=NC=N2

Description

4-Chloro-5-methylthieno[2,3-d]pyrimidine features a fused thienopyrimidine core with orthogonal electron-withdrawing and electron-donating substituents, enabling selective functionalization in medicinal chemistry. This scaffold exhibits enhanced metabolic stability and favorable solubility profiles under standard conditions, facilitating direct incorporation into kinase inhibitor and antiviral lead compounds.

Application

4-Chloro-5-methylthieno[2,3-d]pyrimidine serves as a versatile building block for heterocyclic synthesis, enabling efficient construction of biologically relevant scaffolds. Its chloro group facilitates nucleophilic substitution reactions, while the methyl substituent enhances solubility and modulates electronic properties. The fused thienopyrimidine core provides structural rigidity and metabolic stability, making it valuable in medicinal chemistry campaigns targeting kinase inhibitors and antiviral agents. Bench-stable and compatible with standard coupling protocols, it simplifies purification and scale-up workflows.

Synthesis

Route1
- 43088-64-8
- ~39%
- In-stock
  
  43088-67-1
References
- JE IL PHARMACEUTICAL CO., LTD. Patent: WO2007/102679 A1, 2007 ; Location in patent: Page/Page column 49 ; WO 2007/102679 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 25.78
LogP 2.65312
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Key Words

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4-Chloro-5-methylthieno[2,3-d]pyrimidine

CAS No. 43088-67-1

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