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CS-W001157 4
Total: USD 88.00

5-Amino-2-chloropyrimidine

  • CAS No. 56621-90-0

  • Cat. No. CS-W005338
  • Molecule weight129.55
  • Purity≥97%
  • MDL No.MFCD06412560

*For research and further manufacturing use only, not for direct human use.

5-Amino-2-chloropyrimidine|CS-W005338

Structure of 56621-90-0

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General Information

  • CAS No. 56621-90-0
  • Cat. No. CS-W005338
  • Purity ≥97%
  • MDL No. MFCD06412560
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄ClN₃
  • Molecular Weight 129.55
  • Synonym(s) 5-Pyrimidinamine, 2-chloro- (9CI)
  • SMILES NC1=CN=C(N=C1)Cl

Description

5-Amino-2-chloropyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, integrating an electron-rich amino group with a reactive chloro substituent. This combination enables direct functionalization via nucleophilic substitution or coupling reactions, facilitating rapid diversification in drug discovery and agrochemical development. The molecule exhibits favorable solubility and stability under standard bench conditions.

Application

5-Amino-2-chloropyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. The amino group facilitates nucleophilic substitution and coupling reactions, while the chloro substituent provides a reliable handle for transition-metal-catalyzed transformations. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for iterative synthesis workflows and API development.

Synthesis

  • Route1

    References

    • Pathway Therapeutics Limited Patent: US2011/9405 A1, 2011 ; Location in patent: Page/Page column 56 ;
  • Route2

    References

    • US2003/181465 A1, ; US 20030181465 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.7122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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