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CS-W001157 4
Total: USD 88.00

6-Methylindolin-2-one

  • CAS No. 56341-38-9

  • Cat. No. CS-W003519
  • Purity≥95%
  • MDL No.MFCD08457972

*For research and further manufacturing use only, not for direct human use.

6-Methylindolin-2-one|CS-W003519

Structure of 56341-38-9

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General Information

  • CAS No. 56341-38-9
  • Cat. No. CS-W003519
  • Purity ≥95%
  • MDL No. MFCD08457972
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO
  • Molecular Weight 147.17
  • Synonym(s) 6-METHYLOXINDOLE
  • SMILES O=C1Cc2c(N1)cc(cc2)C

Description

6-Methylindolin-2-one is a bench-stable, electron-rich heterocycle featuring a fused indoline core with a methyl group at the 6-position. This scaffold integrates readily into medicinal chemistry libraries, offering favorable solubility and metabolic stability for targeted molecular design.

Application

6-Methylindolin-2-one serves as a versatile scaffold in medicinal chemistry, enabling rapid access to bioactive indoline derivatives. Its stability and compatibility with diverse functional groups facilitate straightforward derivatization via nucleophilic substitution, reductive amination, and transition-metal-catalyzed coupling reactions. The molecule functions as a key building block for heterocyclic libraries and API intermediates, offering predictable reactivity and ease of purification in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      121989-34-2
    • ~88%
    • In-stock
      6-Methylindolin-2-one|CS-W003519
      56341-38-9

    References

    • Kawase, Masami; Kitamura, Takahiro; Kikugawa, Yasuo Journal of Organic Chemistry, 1989 , vol. 54, # 14 p. 3394 - 3403
  • Route2
    • 2-(4-Methyl-2-Nitrophenyl)acetic acid|CS-0757180
      29640-90-2
    • ~%
    • In-stock
      6-Methylindolin-2-one|CS-W003519
      56341-38-9

    References

    • Journal of the American Chemical Society, , vol. 73, p. 4511,4514
  • Route3
    • null|null
      119114-52-2
    • ~%
    • In-stock
      6-Methylindolin-2-one|CS-W003519
      56341-38-9

    References

    • Journal of Organic Chemistry, , vol. 54, # 14 p. 3394 - 3403

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.48962
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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