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CS-W001157 4
Total: USD 88.00

3-Cyclopropylpropanoic acid

  • CAS No. 5618-03-1

  • Cat. No. CS-D0289
  • Purity≥97%
  • MDL No.MFCD02179408

*For research and further manufacturing use only, not for direct human use.

3-Cyclopropylpropanoic acid|CS-D0289

Structure of 5618-03-1

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General Information

  • CAS No. 5618-03-1
  • Cat. No. CS-D0289
  • Purity ≥97%
  • MDL No. MFCD02179408
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight 114.14
  • Synonym(s) Cyclopropanepropanoic acid
  • SMILES O=C(O)CCC1CC1

Description

3-Cyclopropylpropanoic acid features a cyclopropyl ring tethered to a propanoic acid chain, delivering a rigid, electron-rich motif ideal for bioactive molecule design. This structural unit enhances metabolic stability and modulates lipophilicity in pharmaceutical scaffolds. The compound is bench-stable and readily integrates into synthetic workflows without requiring specialized handling.

Application

3-Cyclopropylpropanoic acid serves as a valuable building block in medicinal chemistry, enabling the incorporation of a rigid cyclopropyl moiety adjacent to a carboxylic acid functional group. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of amides, esters, and other derivatives. The molecule functions effectively in the construction of bioactive scaffolds where conformational restriction enhances target affinity and metabolic stability.

Synthesis

  • Route1

    References

    • US5221671 A1, ; US 5221671 A
  • Route2

    References

    • Justus Liebigs Annalen der Chemie, , vol. 759, p. 132 - 157
  • Route3

    References

    • Justus Liebigs Annalen der Chemie, , vol. 759, p. 132 - 157

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.2612
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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