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CS-W001157 4
Total: USD 88.00

2,4,5-Trichloropyridine

  • CAS No. 55934-01-5

  • Cat. No. CS-W021494
  • Purity≥98%
  • MDL No.MFCD09028037

*For research and further manufacturing use only, not for direct human use.

2,4,5-Trichloropyridine|CS-W021494

Structure of 55934-01-5

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General Information

  • CAS No. 55934-01-5
  • Cat. No. CS-W021494
  • Purity ≥98%
  • MDL No. MFCD09028037
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Cl₃N
  • Molecular Weight 182.44
  • Synonym(s) None
  • SMILES ClC1=CN=C(Cl)C=C1Cl

Description

2,4,5-Trichloropyridine is a chlorinated heterocyclic compound featuring three chlorine substituents at key positions on the pyridine ring. This electron-deficient architecture enables selective coupling reactions in synthetic organic chemistry. The molecule exhibits enhanced stability under standard conditions and serves as a robust building block for pharmaceutical intermediates and agrochemicals.

Application

2,4,5-Trichloropyridine serves as a versatile building block in synthetic organic chemistry, enabling selective functionalization at the pyridine ring due to its electron-deficient nature. The trichloro substitution pattern facilitates nucleophilic aromatic substitution under mild conditions, allowing efficient access to substituted pyridines and heterocyclic scaffolds relevant to agrochemicals and pharmaceutical intermediates. Its bench-stable solid form and compatibility with diverse coupling reactions make it a practical choice for multi-step synthesis.

Synthesis

  • Route1

    References

    • GLAXO GROUP LIMITED; AMANTINI, David; DI FABIO, Romano Patent: WO2010/122151 A1, 2010 ; Location in patent: Page/Page column 66-67 ; WO 2010/122151 A1
  • Route2

    References

    • Kolder; den Hertog Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 285,291
  • Route3

    References

    • Kolder; den Hertog Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 285,291

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.0418
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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