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CS-W001157 4
Total: USD 88.00

4-Bromo-3-(trifluoromethyl)benzaldehyde

  • CAS No. 34328-47-7

  • Cat. No. CS-W022099
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-(trifluoromethyl)benzaldehyde|CS-W022099

Structure of 34328-47-7

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General Information

  • CAS No. 34328-47-7
  • Cat. No. CS-W022099
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrF₃O
  • Molecular Weight 253.02
  • Synonym(s) 4-Bromo-α,α,α-trifluoro-m-tolualdehyde
  • SMILES O=CC1=CC=C(Br)C(C(F)(F)F)=C1

Description

4-Bromo-3-(trifluoromethyl)benzaldehyde features a trifluoromethyl group flanking a bromine-substituted benzene ring, delivering enhanced electron-withdrawing character and stability. This aldehyde integrates readily into cross-coupling reactions and serves as a key intermediate in pharmaceutical and agrochemical synthesis.

Application

4-Bromo-3-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its compatible bromo and aldehyde functionalities. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the aldehyde facilitates subsequent condensation or reductive amination steps. Bench-stable and readily purified by column chromatography, it functions efficiently in standard synthetic workflows for heterocycle synthesis and API intermediate construction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.2804
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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