2-Chloro-4-hydroxypyrimidine

Name: 2-Chloro-4-hydroxypyrimidine
Brand: ChemScene
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CAS No. 55873-09-1
Cat. No. CS-W019681
Purity≥95%
MDL No.MFCD09038284

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 55873-09-1
Cat. No. CS-W019681
Purity ≥95%
MDL No. MFCD09038284
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₃ClN₂O
Molecular Weight 130.53
Synonym(s) Pazopanib Impurity 28
SMILES ClC1=NC=CC(O)=N1

Description

2-Chloro-4-hydroxypyrimidine serves as a key heterocyclic building block for medicinal chemistry and agrochemical synthesis. The chlorine at the 2-position enables efficient nucleophilic substitution, while the adjacent hydroxyl group offers a handle for derivatization. This combination facilitates direct incorporation into bioactive scaffolds with enhanced solubility and metabolic stability under standard bench conditions.

Application

2-Chloro-4-hydroxypyrimidine serves as a versatile building block in heterocyclic synthesis, enabling efficient functionalization at the C4 position via nucleophilic substitution. Its chlorine atom exhibits high reactivity toward amines, alcohols, and thiols, facilitating the construction of diverse pyrimidine derivatives. The hydroxyl group provides additional handle for derivatization or protection, enhancing synthetic flexibility. This compound demonstrates excellent bench stability and compatibility with standard reaction conditions, making it a reliable intermediate in medicinal chemistry and agrochemical development workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 46.01
LogP 0.8356
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-4-hydroxypyrimidine

CAS No. 55873-09-1

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