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CS-W001157 4
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6-Aminopyridin-3-ol

  • CAS No. 55717-46-9

  • Cat. No. CS-W006181
  • Purity≥95%
  • MDL No.MFCD03541056

*For research and further manufacturing use only, not for direct human use.

6-Aminopyridin-3-ol|CS-W006181

Structure of 55717-46-9

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General Information

  • CAS No. 55717-46-9
  • Cat. No. CS-W006181
  • Purity ≥95%
  • MDL No. MFCD03541056
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O
  • Molecular Weight 110.11
  • Synonym(s) 2-Amino-5-hydroxy-pyridin
  • SMILES OC1=CC=C(N)N=C1

Description

6-Aminopyridin-3-ol features a strategically positioned amino group flanking a phenolic hydroxyl, enabling dual functionality in synthetic applications. This electron-rich heterocycle integrates readily into molecular architectures requiring hydrogen-bonding capacity and directional reactivity. The compound exhibits enhanced solubility and stability under standard conditions, facilitating use in medicinal chemistry and materials synthesis workflows.

Application

6-Aminopyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling direct incorporation of both amino and hydroxyl functionalities into heterocyclic scaffolds. Its dual functionality supports diverse transformations including Suzuki-Miyaura coupling, amide formation, and electrophilic substitution, with demonstrated stability under standard bench conditions. The compound facilitates efficient synthesis of pyridine-based API candidates and functionalized intermediates, particularly in the development of kinase inhibitors and antiviral agents.

Synthesis

  • Route1

    References

    • Tibotec Pharmaceuticals Ltd. Patent: WO2007/113290 A1, 2007 ; Location in patent: Page/Page column 40; 42 ;
  • Route2
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    • In-stock
      6-Aminopyridin-3-ol|CS-W006181
      55717-46-9

    References

    • Journal of the American Chemical Society, , vol. 81, p. 6049,6053
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 6049,6053

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.14
  • LogP   0.3694
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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