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CS-W001157 4
Total: USD 88.00

1-Isopropylpiperidin-4-ol

  • CAS No. 5570-78-5

  • Cat. No. CS-W019184
  • Purity≥97%
  • MDL No.MFCD00101977

*For research and further manufacturing use only, not for direct human use.

1-Isopropylpiperidin-4-ol|CS-W019184

Structure of 5570-78-5

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General Information

  • CAS No. 5570-78-5
  • Cat. No. CS-W019184
  • Purity ≥97%
  • MDL No. MFCD00101977
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₇NO
  • Molecular Weight 143.23
  • Synonym(s) N-isopropyl-4-hydroxypiperidine
  • SMILES CC(C)N1CCC(O)CC1

Description

1-Isopropylpiperidin-4-ol is a sterically hindered, bench-stable piperidine derivative featuring a secondary alcohol at the 4-position. This structural motif enables direct incorporation into complex molecular architectures, particularly in medicinal chemistry scaffolds where enhanced solubility and metabolic stability are critical.

Application

1-Isopropylpiperidin-4-ol serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive molecules through established functional group transformations. Its piperidinol core exhibits favorable solubility and metabolic stability, while the isopropyl substituent enhances lipophilicity and steric profile. The compound functions as a key building block in the synthesis of kinase inhibitors and CNS-targeted therapeutics, offering robust bench stability and compatibility with standard coupling protocols.

Synthesis

  • Route1
    • null|null
      5382-16-1
    • null|null
      67-64-1
    • ~97%
    • In-stock
      1-Isopropylpiperidin-4-ol|CS-W019184
      5570-78-5

    References

    • PFIZER LIMITED Patent: WO2007/52124 A1, 2007 ; Location in patent: Page/Page column 17 ; WO 2007/052124 A1
  • Route2
    • null|null
      5382-16-1
    • null|null
      75-26-3
    • ~81%
    • In-stock
      1-Isopropylpiperidin-4-ol|CS-W019184
      5570-78-5

    References

    • Warner-Lambert Company LLC Patent: EP1593679 A1, 2005 ; Location in patent: Page/Page column 39 ; EP 1593679 A1
  • Route3
    • null|null
      5355-68-0
    • ~66%
    • In-stock
      1-Isopropylpiperidin-4-ol|CS-W019184
      5570-78-5

    References

    • Dvorak, Curt A.; Apodaca, Richard; Barbier, Ann J.; Berridge, Craig W.; Wilson, Sandy J.; Boggs, Jamin D.; Xiao, Wei; Lovenberg, Timothy W.; Carruthers, Nicholas I. Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2229 - 2238

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.8515
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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