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CS-W001157 4
Total: USD 88.00

1-Methylpiperidin-4-ol

  • CAS No. 106-52-5

  • Cat. No. CS-W019412
  • Purity≥95%
  • MDL No.MFCD00006500

*For research and further manufacturing use only, not for direct human use.

1-Methylpiperidin-4-ol|CS-W019412

Structure of 106-52-5

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General Information

  • CAS No. 106-52-5
  • Cat. No. CS-W019412
  • Purity ≥95%
  • MDL No. MFCD00006500
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO
  • Molecular Weight None
  • Synonym(s) N-Methyl-4-piperidinol
  • SMILES OC1CCN(C)CC1

Application

1-Methylpiperidin-4-ol serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization pathways. Its bench-stable nature and favorable solubility profile facilitate straightforward purification and integration into multi-step syntheses. The molecule functions as a key scaffold for developing targeted therapeutics, particularly in CNS-directed drug discovery, where its polar, hydrogen-bonding capabilities enhance binding affinity and membrane permeability.

Synthesis

  • Route1
    • 1-Methyl-1,4-Dihydropyridin-4-one|CS-0764214
      695-19-2
    • ~%
    • In-stock
      1-Methylpiperidin-4-ol|CS-W019412
      106-52-5

    References

    • Yakugaku Zasshi, , vol. 71, p. 1097 Chem.Abstr., , p. 5042
  • Route2
    • null|null
      1445-73-4
    • ~69%
    • In-stock
      1-Methylpiperidin-4-ol|CS-W019412
      106-52-5

    References

    • Singh, Satendra; Basmadjian, Garo P.; Avor, Kwasi S.; Pouw, Buddy; Seale, Thomas W. Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2474 - 2481
  • Route3
    • null|null
      1445-73-4
    • null|null
      74497-02-2
    • ~10%
    • In-stock
      1-Methylpiperidin-4-ol|CS-W019412
      106-52-5
    • null|null
      22261-94-5

    References

    • Pharmaceutical Chemistry Journal, , vol. 34, # 2 p. 76 - 78

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.0729
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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