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CS-W001157 4
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Thiazol-2-ylmethanamine

  • CAS No. 55661-33-1

  • Cat. No. CS-W013635
  • Purity≥97%
  • MDL No.MFCD02854204

*For research and further manufacturing use only, not for direct human use.

Thiazol-2-ylmethanamine|CS-W013635

Structure of 55661-33-1

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General Information

  • CAS No. 55661-33-1
  • Cat. No. CS-W013635
  • Purity ≥97%
  • MDL No. MFCD02854204
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆N₂S
  • Molecular Weight 114.17
  • Synonym(s) 1-(1,3-Thiazol-2-yl)methanamine
  • SMILES NCC1=NC=CS1

Description

Thiazol-2-ylmethanamine delivers a reactive thiazole scaffold with a primary amine handle, enabling direct conjugation in bioconjugation and medicinal chemistry. This bench-stable derivative integrates readily into heterocyclic frameworks, offering enhanced solubility and nucleophilic character for targeted molecular design.

Application

Thiazol-2-ylmethanamine serves as a versatile building block in medicinal chemistry, enabling the construction of thiazole-containing scaffolds prevalent in bioactive molecules. Its primary amine functionality facilitates straightforward derivatization via amidation, alkylation, and reductive amination, while the heterocyclic core offers favorable metabolic stability and hydrogen-bonding capacity. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthesis campaigns and lead optimization workflows.

Synthesis

  • Route1
    • null|null
      171268-82-9
    • null|null
      7732-18-5
    • ~72%
    • In-stock
      Thiazol-2-ylmethanamine|CS-W013635
      55661-33-1

    References

    • Pfizer Inc. Patent: US5698526 A1, 1997 ;
  • Route2
    • 1,3-Thiazole-2-carbaldehyde oxime|CS-0770489
      13838-77-2
    • ~81%
    • In-stock
      Thiazol-2-ylmethanamine|CS-W013635
      55661-33-1

    References

    • Dondoni, Alessandro; Merchan, Francisco L.; Merino, Pedro; Rojo, Isabel; Tejero, Tomas Synthesis, 1996 , # 5 p. 641 - 646
  • Route3
    • null|null
      107-20-0
    • N-(2-Amino-2-thioxoethyl)benzamide|CS-0294997
      55443-42-0
    • ~%
    • In-stock
      Thiazol-2-ylmethanamine|CS-W013635
      55661-33-1

    References

    • Journal of the American Chemical Society, , vol. 72, p. 4526,4528

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.6018
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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