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CS-W001157 4
Total: USD 88.00

(2-Methylpyridin-4-yl)methanamine

  • CAS No. 94413-70-4

  • Cat. No. CS-0104071
  • Purity≥97%
  • MDL No.MFCD06637475

*For research and further manufacturing use only, not for direct human use.

(2-Methylpyridin-4-yl)methanamine|CS-0104071

Structure of 94413-70-4

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General Information

  • CAS No. 94413-70-4
  • Cat. No. CS-0104071
  • Purity ≥97%
  • MDL No. MFCD06637475
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight 122.17
  • Synonym(s) 4-Aminomethyl-2-methylpyridine
  • SMILES NCC1=CC(C)=NC=C1

Description

(2-Methylpyridin-4-yl)methanamine features a pyridine ring bearing a methyl group at the 2-position and a primary amine attached to a methylene linker at the 4-position. This configuration imparts enhanced solubility and directional electronic modulation, enabling efficient integration into pharmaceutical scaffolds. The compound serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and GPCR-targeted ligands.

Application

(2-Methylpyridin-4-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. Its primary amine functionality facilitates straightforward derivatization via amidation, alkylation, and reductive amination. The 2-methylpyridin-4-yl scaffold provides favorable electronic and steric properties for target engagement, while the compound exhibits good bench stability and ease of purification—ideal for high-throughput synthesis and lead optimization workflows.

Synthesis

  • Route1

    References

    • Ochiai; Suzuki Pharmaceutical Bulletin, 1954 , vol. 2, p. 147
  • Route2

    References

    • Ochiai; Suzuki Pharmaceutical Bulletin, 1954 , vol. 2, p. 147
  • Route3

    References

    • Ochiai; Suzuki Pharmaceutical Bulletin, 1954 , vol. 2, p. 147

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.84872
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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