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CS-W001157 4
Total: USD 88.00

8-Oxa-3-azabicyclo[3.2.1]octane hydrochloride

  • CAS No. 54745-74-3

  • Cat. No. CS-W005626
  • Purity≥97%
  • MDL No.MFCD09800611

*For research and further manufacturing use only, not for direct human use.

8-Oxa-3-azabicyclo[3.2.1]octane hydrochloride|CS-W005626

Structure of 54745-74-3

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General Information

  • CAS No. 54745-74-3
  • Cat. No. CS-W005626
  • Purity ≥97%
  • MDL No. MFCD09800611
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO
  • Molecular Weight 149.62
  • Synonym(s) T56 A AO GMTJ &&HCl
  • SMILES [C@@H]12CC[C@H](CNC2)O1.Cl

Description

8-Oxa-3-azabicyclo[3.2.1]octane hydrochloride is a rigid, nitrogen-containing heterocycle featuring a bridged oxygen atom and a protonated amine. This structure imparts enhanced solubility and metabolic stability, making it a valuable scaffold in medicinal chemistry for targeting GPCRs and ion channels.

Application

8-Oxa-3-azabicyclo[3.2.1]octane hydrochloride serves as a rigid, conformationally constrained scaffold for medicinal chemistry applications. Its bridged structure provides enhanced metabolic stability and defined spatial orientation of substituents, facilitating targeted interactions in biological systems. The compound exhibits excellent bench stability, tolerates a range of functional groups, and enables efficient derivatization via nucleophilic substitution or reductive amination. This makes it a practical building block for the synthesis of bioactive heterocycles and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.559
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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