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CS-W001157 4
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8-Oxa-3-azabicyclo[3.2.1]octane

  • CAS No. 280-13-7

  • Cat. No. CS-M0310
  • Purity≥98%
  • MDL No.MFCD09836264

*For research and further manufacturing use only, not for direct human use.

8-Oxa-3-azabicyclo[3.2.1]octane|CS-M0310

Structure of 280-13-7

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General Information

  • CAS No. 280-13-7
  • Cat. No. CS-M0310
  • Purity ≥98%
  • MDL No. MFCD09836264
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) None
  • SMILES [C@@H]12CC[C@H](CNC2)O1

Description

8-Oxa-3-azabicyclo[3.2.1]octane features a rigid, polar heterocyclic framework that integrates an oxygen atom and a nitrogen heteroatom within a strained bicyclic scaffold. This configuration imparts enhanced solubility and conformational control, enabling efficient incorporation into bioactive molecules. The scaffold serves as a stable, metabolically resilient core in medicinal chemistry applications.

Application

8-Oxa-3-azabicyclo[3.2.1]octane serves as a rigid, bicyclic scaffold with defined stereochemistry, enabling precise spatial orientation of functional groups in medicinal chemistry applications. The molecule features an oxygen atom at the bridgehead and a nitrogen within the ring system, providing a polar, hydrogen-bond-capable site for molecular recognition. Its bench-stable structure facilitates straightforward derivatization, supports orthogonal functional group handling, and functions effectively in standard coupling and reduction protocols. This scaffold is particularly valuable for constructing bioactive heterocycles and modulating pharmacokinetic properties in lead optimization.

Synthesis

  • Route1
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      1472-00-0
    • ~%
    • In-stock
      8-Oxa-3-azabicyclo[3.2.1]octane|CS-M0310
      280-13-7

    References

    • Newth; Wiggins Journal of the Chemical Society, 1948 , p. 155,157
  • Route2

    References

    • Newth; Wiggins Journal of the Chemical Society, 1948 , p. 155,157
  • Route3
    • null|null
      7664-41-7
    • null|null
      1472-00-0
    • ~%
    • In-stock
      8-Oxa-3-azabicyclo[3.2.1]octane|CS-M0310
      280-13-7

    References

    • Wiggins; Wood Journal of the Chemical Society, 1950 , p. 1566,1572 Full Text Show Details Newth; Wiggins Journal of the Chemical Society, 1948 , p. 155,157

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P261-P305+P351+P338

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.1372
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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