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CS-W001157 4
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3-oxa-8-azabicyclo[3.2.1]octane hydrochloride

  • CAS No. 904316-92-3

  • Cat. No. CS-W003900
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-oxa-8-azabicyclo[3.2.1]octane hydrochloride|CS-W003900

Structure of 904316-92-3

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General Information

  • CAS No. 904316-92-3
  • Cat. No. CS-W003900
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO
  • Molecular Weight 149.62
  • Synonym(s) 8-oxa-3-aza-bicyclo
  • SMILES O1CC2CCC(C1)N2.Cl

Description

3-Oxa-8-azabicyclo[3.2.1]octane hydrochloride is a rigid, nitrogen-containing heterocycle featuring an embedded oxygen atom and a protonated amine, offering enhanced solubility and stability under standard conditions. This scaffold integrates seamlessly into medicinal chemistry campaigns requiring constrained, polarizable ring systems with defined stereochemistry and improved bioavailability.

Application

3-Oxa-8-azabicyclo[3.2.1]octane hydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to constrained nitrogen-containing scaffolds. Its bicyclic structure provides rigidity and enhanced metabolic stability, while the protonated amine enhances solubility and facilitates salt formation. The molecule functions effectively in nucleophilic displacement reactions and supports diverse functionalization at the 3- and 8-positions, making it valuable for synthesizing bioactive compounds and peptide mimetics under standard bench conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.559
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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