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CS-W001157 4
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3-Oxa-8-azabicyclo[3.2.1]octane

  • CAS No. 280-07-9

  • Cat. No. CS-0054659
  • Purity≥98%
  • MDL No.MFCD18250273

*For research and further manufacturing use only, not for direct human use.

3-Oxa-8-azabicyclo[3.2.1]octane|CS-0054659

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General Information

  • CAS No. 280-07-9
  • Cat. No. CS-0054659
  • Purity ≥98%
  • MDL No. MFCD18250273
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) 3-OXA-8-AZABICYCLO[3.2.1]OCTAN
  • SMILES [C@@H]12CC[C@H](COC2)N1

Description

3-Oxa-8-azabicyclo[3.2.1]octane features a rigid, bridged heterocyclic framework combining oxygen and nitrogen atoms in a strained ring system. This configuration imparts high stability and unique electronic properties, enabling precise spatial control in synthetic applications. The molecule serves as a privileged scaffold in medicinal chemistry, facilitating the design of conformationally restricted bioactive compounds.

Application

3-Oxa-8-azabicyclo[3.2.1]octane serves as a rigid, conformationally constrained scaffold in medicinal chemistry, enabling precise spatial orientation of functional groups. Its oxazine core exhibits favorable metabolic stability and moderate lipophilicity, facilitating integration into bioactive molecules. The bicyclic framework tolerates diverse substitutions and participates reliably in standard coupling reactions, supporting efficient route optimization for target-directed synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.1372
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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