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Structure of 54435-09-5
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2-Iodo-4-methoxybenzoic acid features a reactive iodine atom at the ortho position relative to a carboxylic acid group, paired with a para-methoxy substituent that enhances electron density. This combination enables efficient cross-coupling reactions in late-stage functionalization, particularly under palladium catalysis. The molecule exhibits good stability under standard bench conditions and facilitates direct incorporation into complex molecular architectures without requiring protective group manipulations.
2-Iodo-4-methoxybenzoic acid serves as a versatile building block for Suzuki-Miyaura and Stille coupling reactions, enabling the construction of biaryl and heteroaryl scaffolds under standard catalytic conditions. The iodide group exhibits high reactivity with palladium catalysts, while the carboxylic acid and methoxy functionalities provide orthogonal handles for further derivatization. Bench-stable and readily purified by recrystallization, it facilitates efficient access to functionalized aromatic systems in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H315-H319-H331-H335
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: