Lot numbers can be found on the outside label of a product:
2-Iodo-4-methoxybenzoic acid
-
CAS No. 54435-09-5
- Cat. No. CS-W005751
- Purity≥95%
- MDL No.MFCD09909619
*For research and further manufacturing use only, not for direct human use.
Structure of 54435-09-5
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 54435-09-5
- Cat. No. CS-W005751
- Purity ≥95%
- MDL No. MFCD09909619
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₇IO₃
- Molecular Weight 278.04
- Synonym(s) Benzoic acid,2-iodo-4-methoxy
- SMILES COC1=CC(I)=C(C=C1)C(O)=O
Description
2-Iodo-4-methoxybenzoic acid features a reactive iodine atom at the ortho position relative to a carboxylic acid group, paired with a para-methoxy substituent that enhances electron density. This combination enables efficient cross-coupling reactions in late-stage functionalization, particularly under palladium catalysis. The molecule exhibits good stability under standard bench conditions and facilitates direct incorporation into complex molecular architectures without requiring protective group manipulations.
Application
2-Iodo-4-methoxybenzoic acid serves as a versatile building block for Suzuki-Miyaura and Stille coupling reactions, enabling the construction of biaryl and heteroaryl scaffolds under standard catalytic conditions. The iodide group exhibits high reactivity with palladium catalysts, while the carboxylic acid and methoxy functionalities provide orthogonal handles for further derivatization. Bench-stable and readily purified by recrystallization, it facilitates efficient access to functionalized aromatic systems in medicinal chemistry and materials science applications.
Synthesis
-
Route1
-
In-stock
4294-95-5 - ~%
-
In-stock
54435-09-5
References
-
Koizumi,J. et al. Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, # 6 p. 696 - 705
-
-
Route2
-
In-stock
105469-13-4 - ~99%
-
In-stock
54435-09-5
References
-
Liang, Pi-Hui; Hsin, Ling-Wei; Pong, Sung-Ling; Hsu, Chia-Huei; Cheng, Chen-Yu Journal of the Chinese Chemical Society, 2003 , vol. 50, # 3 A p. 449 - 456
-
-
Route3
-
7664-93-9 -
In-stock
4294-95-5
- ~%
-
In-stock
54435-09-5
References
-
Sterling Winthrop Inc. Patent: US5614530 A1, 1997 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS06
|
|
Signal Word : Danger
|
UN#: 3439
|
|
Class : 6.1
|
Packing Group : Ⅲ
|
|
Hazard Statements : H302+H312-H315-H319-H331-H335
|
|
|
Precautionary Statements : P264-P270-P330-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 46.53
- LogP 1.998
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 2
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 2-Iodo-4-methoxybenzoic acid sigma2-Iodo-4-methoxybenzoic acid manufacturer2-Iodo-4-methoxybenzoic acid price2-Iodo-4-methoxybenzoic acid structure2-Iodo-4-methoxybenzoic acid SDSbuy 2-Iodo-4-methoxybenzoic acid2-Iodo-4-methoxybenzoic acid supplier2-Iodo-4-methoxybenzoic acid uses2-Iodo-4-methoxybenzoic acid molecular weightprice of 2-Iodo-4-methoxybenzoic acid2-Iodo-4-methoxybenzoic acid chemical name formula of 2-Iodo-4-methoxybenzoic acid