Lot numbers can be found on the outside label of a product:
Quinoxalin-2-amine
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CAS No. 5424-05-5
- Cat. No. CS-W022950
- Purity≥97%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 5424-05-5
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General Information
- CAS No. 5424-05-5
- Cat. No. CS-W022950
- Purity ≥97%
- MDL No. None
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₇N₃
- Molecular Weight 145.16
- Synonym(s) 2-Aminoquinoxaline
- SMILES NC1=NC2=C(C=CC=C2)N=C1
Description
Quinoxalin-2-amine delivers a rigid, electron-rich heteroaromatic scaffold ideal for constructing bioactive molecules. This bench-stable derivative features a strategically positioned amine group enabling direct functionalization, facilitating integration into pharmaceutical intermediates and advanced materials through straightforward coupling reactions.
Application
Quinoxalin-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to quinoxaline-based scaffolds through straightforward coupling and functionalization reactions. Its amine functionality facilitates conjugation with electrophiles, while the rigid fused-ring system provides structural stability and favorable pharmacophore geometry for target engagement. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.
Synthesis
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Route1
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101101-68-2 - ~24%
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In-stock
5424-05-5
References
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BIOLIPOX AB Patent: WO2007/51982 A1, 2007 ; Location in patent: Page/Page column 39 ;
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Route2
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In-stock
1448-87-9 - ~69%
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In-stock
5424-05-5
References
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Cheung, Chi Wai; Surry, David S.; Buchwald, Stephen L. Organic Letters, 2013 , vol. 15, # 14 p. 3734 - 3737
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Route3
References
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Adam, Mohamed Shaker S.; Mohamad, Ahmad Desoky; Jones, Peter G.; Kindermann, Markus K.; Heinicke, Joachim W. Polyhedron, 2013 , vol. 50, # 1 p. 101 - 111
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 51.8
- LogP 1.212
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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