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3-Chloroquinoxalin-2-amine

  • CAS No. 34117-90-3

  • Cat. No. CS-0021989
  • Purity≥97%
  • MDL No.MFCD00234398

*For research and further manufacturing use only, not for direct human use.

3-Chloroquinoxalin-2-amine|CS-0021989

Structure of 34117-90-3

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General Information

  • CAS No. 34117-90-3
  • Cat. No. CS-0021989
  • Purity ≥97%
  • MDL No. MFCD00234398
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆ClN₃
  • Molecular Weight 179.61
  • Synonym(s) 2 CHLORO-3-AMINO QUINOXALINE
  • SMILES NC1=NC2=CC=CC=C2N=C1Cl

Description

3-Chloroquinoxalin-2-amine is a bench-stable heterocyclic amine featuring a chlorinated quinoxaline core. This electron-deficient scaffold integrates readily into medicinal chemistry libraries, enabling direct coupling with nucleophiles in cross-coupling reactions. The para-chloro group facilitates further functionalization, while the pendant amine serves as a versatile handle for conjugation.

Application

3-Chloroquinoxalin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to quinoxaline-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates direct functionalization under mild conditions, while the amino group offers opportunities for derivatization via acylation, alkylation, or further coupling. The compound exhibits good bench stability and is compatible with standard purification methods, making it a practical choice for the synthesis of bioactive heterocycles and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.8654
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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