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N-Fmoc-N-(2-phenylethyl)-glycine

  • CAS No. 540483-58-7

  • Cat. No. CS-0163398
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-Fmoc-N-(2-phenylethyl)-glycine|CS-0163398

Structure of 540483-58-7

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General Information

  • CAS No. 540483-58-7
  • Cat. No. CS-0163398
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₃NO₄
  • Molecular Weight 401.45
  • Synonym(s) N-α-(9-Fluorenylmethoxycarbonyl)-N-α-phenethylglycine
  • SMILES O=C(O)CN(C(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)CCC4=CC=CC=C4

Description

N-Fmoc-N-(2-phenylethyl)-glycine features a protected glycine scaffold with orthogonal functionality, combining the Fmoc group for traceless deprotection and a benzylic amine handle. This bifunctional design enables seamless incorporation into peptide synthesis and conjugation workflows, offering high stability and efficient coupling under standard conditions.

Application

N-Fmoc-N-(2-phenylethyl)-glycine serves as a versatile dipeptide building block for solid-phase peptide synthesis and the construction of bioactive peptidomimetics. The Fmoc group enables orthogonal protection for primary amines, while the 2-phenylethyl side chain provides steric and electronic modulation. It exhibits excellent bench stability, facilitates efficient coupling reactions, and supports purification via standard chromatographic methods.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   4.5648
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   7

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