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N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N2-methyl-L-glutamine

  • CAS No. 910056-51-8

  • Cat. No. CS-0166905
  • Purity≥97%
  • MDL No.MFCD30475988

*For research and further manufacturing use only, not for direct human use.

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N2-methyl-L-glutamine|CS-0166905

Structure of 910056-51-8

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General Information

  • CAS No. 910056-51-8
  • Cat. No. CS-0166905
  • Purity ≥97%
  • MDL No. MFCD30475988
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₂N₂O₅
  • Molecular Weight 382.41
  • Synonym(s) FMOC-N-METHYL-L-GLUTAMINE
  • SMILES O=C(N)CC[C@@H](C(O)=O)N(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C

Description

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N2-methyl-L-glutamine is a protected glutamine derivative featuring a fluorenylmethoxycarbonyl (Fmoc) group at the Nα position and a methyl substituent on the side-chain amide. This configuration enables selective incorporation in peptide synthesis, combining enhanced stability with efficient deprotection under mild basic conditions. The Fmoc handle facilitates orthogonal protection strategies in solid-phase workflows.

Application

N₂-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N²-methyl-L-glutamine serves as a protected amino acid building block for peptide synthesis, offering enhanced solubility and stability during coupling reactions. The Fmoc group enables orthogonal deprotection under mild basic conditions, while the N²-methyl substitution reduces racemization risk. This derivative facilitates efficient incorporation of glutamine side chains into complex peptides with high fidelity and ease of purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   109.93
  • LogP   2.586
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   7

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