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CS-W001157 4
Total: USD 88.00

6-Azuridine

  • CAS No. 54-25-1

  • Cat. No. CS-0137595
  • Purity≥98%
  • MDL No.MFCD00006472

*For research and further manufacturing use only, not for direct human use.

6-Azuridine|CS-0137595

Structure of 54-25-1

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General Information

  • CAS No. 54-25-1
  • Cat. No. CS-0137595
  • Purity ≥98%
  • MDL No. MFCD00006472
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁N₃O₆
  • Molecular Weight 245.19
  • Synonym(s) 6-Azauridine
  • SMILES O=C(N1)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)N=CC1=O

Description

6-Azauridine (CAS 54-25-1) inhibits de novo pyrimidine biosynthesis by disrupting ribonucleotide reductase activity and induces DNA damage in proliferating cells during metabolic labeling assays.

Application

6-Azauridine (CAS 54-25-1) blocks the conversion of orotic acid into UMP by inhibiting key enzymes in the pyrimidine biosynthesis pathway. This disrupts nucleotide supply. Researchers leverage this to suppress viral replication in experimental models.

Synthesis

  • Route1

    References

    • Depelley, Jean; Granet, Robert; Kaouadji, Mourad; Krausz, Pierre; Piekarski, Salomon; Delebassee, Sylvie; Bosgiraud, Claudine Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 995 - 1008
  • Route2
    • null|null
      59967-97-4
    • ~88%
    • In-stock
      6-Azuridine|CS-0137595
      54-25-1

    References

    • Drasar, Pavel; Beranek, Jiri Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 2070 - 2082
  • Route3

    References

    • Collection of Czechoslovak Chemical Communications, , vol. 22, p. 1330 - 1332

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H351
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   137.67
  • LogP   -3.4569
  • H_Acceptors   8
  • H_Donors   4
  • Rotatable_Bonds   2

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