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CS-W001157 4
Total: USD 88.00

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine

  • CAS No. 53890-39-4

  • Cat. No. CS-0096418
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine|CS-0096418

Structure of 53890-39-4

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Description

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine features a fused triazolopyridazine core with a chlorine substituent at the 6-position, imparting enhanced electron-withdrawing character. This scaffold serves as a rigid, planar building block for medicinal chemistry applications, particularly in kinase inhibitor design and heterocyclic drug discovery. The amine functionality at position 3 enables direct derivatization, facilitating diverse conjugation strategies under standard coupling conditions.

Application

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical discovery. Its chlorine substituent enables palladium-catalyzed cross-coupling reactions, while the triazolopyridazine core provides a rigid, electron-deficient scaffold with favorable metabolic stability. The amine functionality offers direct handle for derivatization via acylation, alkylation, or Ugi-type condensations, facilitating rapid library synthesis. Bench-stable and readily purified by column chromatography, it supports scalable implementation in target-oriented synthesis.

General Information

  • CAS No. 53890-39-4
  • Cat. No. CS-0096418
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClN₅
  • Molecular Weight 169.57
  • Synonym(s) 6-Chloro[1,2,4]triazolo[4,3-b]pyridazin-3-amine
  • SMILES NC1=NN=C2C=CC(Cl)=NN21

Computational Chemistry Data

  • TPSA   69.1
  • LogP   0.3599
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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