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CS-W001157 4
Total: USD 88.00

3-(Piperazin-1-yl)propan-1-ol

  • CAS No. 5317-32-8

  • Cat. No. CS-W016377
  • Purity≥98%
  • MDL No.MFCD00023132

*For research and further manufacturing use only, not for direct human use.

3-(Piperazin-1-yl)propan-1-ol|CS-W016377

Structure of 5317-32-8

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General Information

  • CAS No. 5317-32-8
  • Cat. No. CS-W016377
  • Purity ≥98%
  • MDL No. MFCD00023132
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂O
  • Molecular Weight 144.22
  • Synonym(s) None
  • SMILES OCCCN1CCNCC1

Description

3-(Piperazin-1-yl)propan-1-ol is a versatile bifunctional building block featuring a piperazine ring linked to a primary alcohol via a three-carbon chain. This structure combines nitrogen-rich heterocyclic character with a reactive hydroxyl group, enabling integration into bioactive molecules, polymer architectures, and medicinal chemistry scaffolds under standard conditions.

Application

3-(Piperazin-1-yl)propan-1-ol serves as a versatile bifunctional building block in medicinal chemistry, enabling the introduction of both polar amine and hydroxyl functionalities. Its piperazine core provides enhanced solubility and hydrogen-bonding capacity, while the primary alcohol facilitates derivatization via esterification, etherification, or coupling reactions. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it a practical choice for constructing complex heterocyclic scaffolds and drug-like molecules.

Synthesis

  • Route1
    • Ethyl 4-(3-hydroxypropyl)piperazine-1-carboxylate|CS-0580184
      7483-27-4
    • ~81%
    • In-stock
      3-(Piperazin-1-yl)propan-1-ol|CS-W016377
      5317-32-8

    References

    • Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; LI, Song; WANG, Hongliang; XIAO, Junhai; ZHANG, Xian; WANG, Lili; ZHENG, Zhibing; ZHONG, Wu; XIE, Yunde; LI, Xingzhou; ZHOU, Xinbo; ZHAO, Guoming; WANG, Xiaokui Patent: EP2602252 A1, 2013 ; Location in patent: Paragraph 0046 ;
  • Route2
    • null|null
      110-85-0
    • In-stock
      3-Bromopropan-1-ol|CS-W007337
      627-18-9
    • ~%
    • In-stock
      3-(Piperazin-1-yl)propan-1-ol|CS-W016377
      5317-32-8

    References

    • US2012/171116 A1, ; Page/Page column 32 ; US 20120171116 A1
  • Route3
    • null|null
      110-85-0
    • ~65%
    • In-stock
      3-(Piperazin-1-yl)propan-1-ol|CS-W016377
      5317-32-8

    References

    • Petrova, L. S.; Davidenkov, L. R.; Medved', S. S. J. Appl. Chem. USSR (Engl. Transl.), 1980 , vol. 53, # 1 p. 199 - 203,174 - 178

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.5
  • LogP   -0.726
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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