tert-Butyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-lysinate hydrochloride

Name: tert-Butyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-lysinate hydrochloride
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CAS No. 2413365-23-6
Cat. No. CS-0182046
Purity≥97%
MDL No.None

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tert-Butyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-lysinate hydrochloride|CS-0182046

Structure of 2413365-23-6

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General Information

CAS No. 2413365-23-6
Cat. No. CS-0182046
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₃₃ClN₂O₄
Molecular Weight 460.99
Synonym(s) Fmoc-Lys-OtBu.HCl
SMILES NCCCC[C@@H](C(OC(C)(C)C)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O.Cl

Description

This fluorenylmethoxycarbonyl-protected lysine derivative enables efficient solid-phase peptide synthesis, featuring a tert-butyl ester that facilitates selective deprotection under mild acidic conditions. The fluoren-9-ylmethoxycarbonyl (Fmoc) group ensures high coupling efficiency and stability during chain elongation, while the hydrochloride salt enhances solubility in common organic solvents.

Application

tert-Butyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-lysinate hydrochloride serves as a robust, bench-stable amino acid derivative enabling efficient N-terminal protection in peptide synthesis. The Fmoc group facilitates orthogonal deprotection under mild basic conditions, while the tert-butyl ester permits selective side-chain modulation. This reagent exhibits excellent solubility and functional group tolerance, streamlining sequence assembly in solid-phase and solution-phase workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 90.65
LogP 4.7862
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 8

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Amine

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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tert-Butyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-lysinate hydrochloride

CAS No. 2413365-23-6

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