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CS-W001157 4
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Methyl 3-(piperazin-1-yl)propanoate dihydrochloride

  • CAS No. 82972-28-9

  • Cat. No. CS-0251008
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 3-(piperazin-1-yl)propanoate dihydrochloride|CS-0251008

Structure of 82972-28-9

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General Information

  • CAS No. 82972-28-9
  • Cat. No. CS-0251008
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈Cl₂N₂O₂
  • Molecular Weight 245.15
  • Synonym(s) methyl 3-(1-piperazinyl)propanoate dihydrochloride
  • SMILES COC(=O)CCN1CCNCC1.Cl.Cl

Description

Methyl 3-(piperazin-1-yl)propanoate dihydrochloride is a bench-stable, moisture-tolerant reagent featuring a piperazine moiety linked to a propanoate ester. This polar, protonated derivative enhances solubility in aqueous and protic solvents, enabling efficient incorporation into peptide conjugation and medicinal chemistry workflows.

Application

Methyl 3-(piperazin-1-yl)propanoate dihydrochloride serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient synthesis of piperazine-containing scaffolds. The piperazinyl group provides enhanced solubility and hydrogen-bonding capacity, while the ester functionality supports downstream transformations such as hydrolysis, amidation, or coupling reactions. Its dihydrochloride salt form enhances stability and facilitates purification, making it well-suited for use in multi-step synthetic sequences targeting bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   0.2983
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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