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CS-W001157 4
Total: USD 88.00

2,3-Dimethoxypyridine

  • CAS No. 52605-97-7

  • Cat. No. CS-W008190
  • Purity≥96%
  • MDL No.MFCD03095043

*For research and further manufacturing use only, not for direct human use.

2,3-Dimethoxypyridine|CS-W008190

Structure of 52605-97-7

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General Information

  • CAS No. 52605-97-7
  • Cat. No. CS-W008190
  • Purity ≥96%
  • MDL No. MFCD03095043
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO₂
  • Molecular Weight 139.15
  • Synonym(s) 2,3-dimethoxypiridine
  • SMILES COC1=CC=CN=C1OC

Description

2,3-Dimethoxypyridine features two methoxy groups at adjacent positions on the pyridine ring, enhancing electron density and reactivity in cross-coupling processes. This bench-stable heterocycle serves as a key scaffold in medicinal chemistry and catalytic synthesis, offering improved solubility and compatibility with transition metal systems.

Application

2,3-Dimethoxypyridine serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient functionalization at the C2 and C3 positions. Its ortho-dimethoxy substitution pattern enhances electrophilic aromatic substitution reactivity while providing robust bench stability and compatibility with standard coupling protocols. The molecule functions as a key scaffold for heterocyclic synthesis and facilitates the construction of complex APIs through directed metallation and cross-coupling reactions.

Synthesis

  • Route1
    • In-stock
      2-Chloro-3-methoxypyridine|CS-W003068
      52605-96-6
    • null|null
      124-41-4
    • ~72%
    • In-stock
      2,3-Dimethoxypyridine|CS-W008190
      52605-97-7

    References

    • Trecourt, Francois; Mallet, Marc; Mongin, Olivier; Queguiner, Guy Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6173 - 6178
  • Route2

    References

    • Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto Tetrahedron, 1985 , vol. 41, # 7 p. 1373 - 1384
  • Route3

    References

    • Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto Tetrahedron, 1985 , vol. 41, # 7 p. 1373 - 1384

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.0988
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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