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2-Methoxypyridin-3-ol

  • CAS No. 13472-83-8

  • Cat. No. CS-0096331
  • Purity≥98%
  • MDL No.MFCD00457990

*For research and further manufacturing use only, not for direct human use.

2-Methoxypyridin-3-ol|CS-0096331

Structure of 13472-83-8

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General Information

  • CAS No. 13472-83-8
  • Cat. No. CS-0096331
  • Purity ≥98%
  • MDL No. MFCD00457990
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂
  • Molecular Weight 125.13
  • Synonym(s) 2-Methoxy-3-pyridinol
  • SMILES OC1=CC=CN=C1OC

Description

2-Methoxypyridin-3-ol features a pyridinol scaffold with a methoxy group at the 2-position, delivering enhanced solubility and stability. This electron-rich heterocycle integrates readily into pharmaceutical intermediates and functional materials, offering predictable reactivity in cross-coupling and derivatization processes under standard conditions.

Application

2-Methoxypyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through established coupling and functionalization protocols. Its ortho-hydroxy and methoxy groups provide complementary reactivity for directed metalation, electrophilic substitution, and transition-metal-catalyzed transformations. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • In-stock
      2-Iodo-3-pyridinol|CS-D1763
      40263-57-8
    • null|null
      124-41-4
    • ~%
    • In-stock
      2-Methoxypyridin-3-ol|CS-0096331
      13472-83-8

    References

    • v. Schickh et al. Chemische Berichte, 1936 , vol. 69, p. 2593,2604
  • Route2

    References

    • v. Schickh et al. Chemische Berichte, 1936 , vol. 69, p. 2593,2604

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.35
  • LogP   0.7958
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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