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CS-W001157 4
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Quinuclidine-2-carboxylic acid hydrochloride

  • CAS No. 52601-23-7

  • Cat. No. CS-0005671
  • Purity≥97%
  • MDL No.MFCD00168044

*For research and further manufacturing use only, not for direct human use.

Quinuclidine-2-carboxylic acid hydrochloride|CS-0005671

Structure of 52601-23-7

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General Information

  • CAS No. 52601-23-7
  • Cat. No. CS-0005671
  • Purity ≥97%
  • MDL No. MFCD00168044
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄ClNO₂
  • Molecular Weight 191.66
  • Synonym(s) 1-Azabicyclo[2.2.2]octane-2-carboxylic acid hydrochloride
  • SMILES O=C(O)C1CC2CCN1CC2.Cl

Description

Quinuclidine-2-carboxylic acid hydrochloride features a rigid, bicyclic quinuclidine core with a carboxylic acid group at the 2-position, delivering enhanced solubility and stability. The hydrochloride salt form ensures excellent handling properties and facilitates use in medicinal chemistry applications.

Application

Quinuclidine-2-carboxylic acid hydrochloride serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through its rigid bicyclic framework and orthogonal functionalization. The carboxylic acid group facilitates direct amidation, esterification, or metal-catalyzed coupling reactions, while the protonated quinuclidine nitrogen enhances solubility and modulates basicity. This compound exhibits excellent bench stability, simplifies purification via salt formation, and functions reliably in standard peptide and small-molecule synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   0.9771
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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