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CS-W001157 4
Total: USD 88.00

2-Bromo-5-fluoro-3-methoxypyridine

  • CAS No. 1256806-73-1

  • Cat. No. CS-0108564
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-fluoro-3-methoxypyridine|CS-0108564

Structure of 1256806-73-1

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General Information

  • CAS No. 1256806-73-1
  • Cat. No. CS-0108564
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFNO
  • Molecular Weight 206.01
  • Synonym(s) None
  • SMILES COC1=CC(F)=CN=C1Br

Description

2-Bromo-5-fluoro-3-methoxypyridine features a strategically positioned bromo and fluoro substituent on a pyridine core, enabling selective cross-coupling reactions. The methoxy group enhances solubility and modulates electronic properties. This bench-stable heterocycle serves as a key intermediate in the synthesis of bioactive compounds and functional materials.

Application

2-Bromo-5-fluoro-3-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine and methoxy substituents offer tunable electronic effects and steric profiles. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.9918
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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