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L-Proline, 1-methyl-5-oxo-

  • CAS No. 52574-06-8

  • Cat. No. CS-0030793
  • Purity≥95%
  • MDL No.MFCD19228297

*For research and further manufacturing use only, not for direct human use.

L-Proline, 1-methyl-5-oxo-|CS-0030793

Structure of 52574-06-8

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General Information

  • CAS No. 52574-06-8
  • Cat. No. CS-0030793
  • Purity ≥95%
  • MDL No. MFCD19228297
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NO₃
  • Molecular Weight 143.14
  • Synonym(s) 1-Methyl-5-oxo-L-Proline
  • SMILES O=C(O)[C@@H](N1C)CCC1=O

Description

(S)-1-Methyl-5-oxopyrrolidine-2-carboxylic acid features a chiral pyrrolidine core with a methylated nitrogen and a ketone-functionalized ring, enabling precise stereochemical control in peptide bond mimicry. This stable, bench-ready scaffold integrates readily into bioactive molecules, offering enhanced metabolic resilience and favorable conformational rigidity for medicinal chemistry applications.

Application

(S)-1-Methyl-5-oxopyrrolidine-2-carboxylic acid serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of pyrrolidinone-containing scaffolds prevalent in bioactive molecules. Its well-defined stereochemistry and stability under standard reaction conditions facilitate efficient incorporation into peptide-like frameworks and heterocyclic systems. Functions as a key intermediate in the construction of kinase inhibitors and CNS-targeted compounds, offering predictable reactivity in amide coupling and reduction processes.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.61
  • LogP   -0.3082
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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