Boc-Pyr-OH

Name: Boc-Pyr-OH
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 53100-44-0
Cat. No. CS-W010389
Purity≥95%
MDL No.MFCD00672316

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 53100-44-0

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General Information

CAS No. 53100-44-0
Cat. No. CS-W010389
Purity ≥95%
MDL No. MFCD00672316
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₅NO₅
Molecular Weight 229.23
Synonym(s) N-Boc-L-pyroglutamic acid
SMILES O=C(N1[C@H](C(O)=O)CCC1=O)OC(C)(C)C

Description

Boc-Pyr-OH is a bench-stable, moisture-tolerant pyrrolidine derivative featuring a tert-butoxycarbonyl-protected amine. This reagent integrates seamlessly into peptide synthesis workflows, enabling efficient incorporation of pyrrolidine units under standard conditions. The Boc group facilitates straightforward deprotection with mild acids, supporting rapid access to functionalized intermediates.

Application

Boc-Pyr-OH serves as a versatile building block for the synthesis of pyrrolidine-containing scaffolds, enabling efficient incorporation of protected nitrogen functionality in medicinal chemistry and natural product synthesis. Its stability under standard reaction conditions and compatibility with diverse coupling protocols facilitate straightforward installation and subsequent deprotection, supporting robust workflow integration in multi-step syntheses.

Synthesis

Route1
- In-stock
  
  113400-36-5
- ~96%
- In-stock
  
  53100-44-0
References
- Bernardi, Fernando; Garavelli, Marco; Scatizzi, Marco; Tomasini, Claudia; Trigari, Valerio; Crisma, Marco; Formaggio, Fernando; Peggion, Cristina; Toniolo, Claudio Chemistry (Weinheim an der Bergstrasse, Germany), 2002 , vol. 8, # 11 p. 2516 - 2525
Route2
- 108963-97-9
- ~80%
- In-stock
  
  53100-44-0
References
- Yoshifuji,Shigeyuki; Tanaka, Ken-ichi; Kawai, Tomoyuki; Nitta, Yoshihiro Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 9 p. 3873 - 3878
Route3
- In-stock
  
  24424-99-5
- ~%
- In-stock
  
  53100-44-0
References
- Bioorganic and Medicinal Chemistry, , vol. 15, # 10 p. 3474 - 3488

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 83.91
LogP 0.9971
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Life Science Amino Acids and their Derivatives Glutamic acid and derivatives

Building Blocks Functional Group Boc

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Boc-Pyr-OH

CAS No. 53100-44-0

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