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CS-W001157 4
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3-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride

  • CAS No. 52407-92-8

  • Cat. No. CS-0051261
  • Molecule weight199.12
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride|CS-0051261

Structure of 52407-92-8

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General Information

  • CAS No. 52407-92-8
  • Cat. No. CS-0051261
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆Cl₂N₂
  • Molecular Weight 199.12
  • Synonym(s) 3-Methyl-3,8-diaza-bicyclo[3.2.1]octane dihydrochloride
  • SMILES Cl.Cl.CN1CC2CCC(C1)N2

Description

3-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride is a sterically hindered, bench-stable nitrogen heterocycle featuring two basic amine centers in a rigid bicyclic framework. This structure enables efficient protonation and strong nucleophilic character, making it ideal for catalytic applications in asymmetric synthesis and as a tunable base in organic transformations.

Application

3-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride serves as a robust, bench-stable nitrogen base and ligand in synthetic organic chemistry. Its rigid bicyclic structure imparts high basicity and selective coordination in transition metal-catalyzed reactions, particularly in cross-coupling and C–H functionalization processes. The dihydrochloride salt enhances solubility and handling while maintaining stability under standard laboratory conditions, facilitating purification and reproducible reaction outcomes in complex molecule synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.896
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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