Lot numbers can be found on the outside label of a product:
4-(2,6-Dichloropyrimidin-4-yl)morpholine
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CAS No. 52127-83-0
- Cat. No. CS-0129824
- Purity≥97%
- MDL No.MFCD09746259
*For research and further manufacturing use only, not for direct human use.
Structure of 52127-83-0
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General Information
- CAS No. 52127-83-0
- Cat. No. CS-0129824
- Purity ≥97%
- MDL No. MFCD09746259
- Storage -20°C, sealed storage, away from moisture and light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₉Cl₂N₃O
- Molecular Weight 234.08
- Synonym(s) 2,4-Dichloro-6-(4-morpholino)pyrimidine
- SMILES ClC1=CC(N2CCOCC2)=NC(Cl)=N1
Description
4-(2,6-Dichloropyrimidin-4-yl)morpholine is a bench-stable heterocyclic building block featuring a morpholine ring tethered to a 2,6-dichloropyrimidine core. This combination delivers enhanced reactivity in nucleophilic substitution and coupling processes, enabling efficient integration into pharmaceutical intermediates and agrochemical scaffolds.
Application
4-(2,6-Dichloropyrimidin-4-yl)morpholine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through palladium-catalyzed cross-coupling reactions. Its dichloropyrimidine core exhibits high reactivity toward nucleophiles, facilitating rapid functionalization under mild conditions. The morpholine moiety provides favorable solubility and metabolic stability, enhancing its utility in drug discovery workflows.
Synthesis
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Route1
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110-91-8 -
In-stock
3764-01-0 - ~85%
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In-stock
52127-83-0
References
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US2006/199804 A1, ; Page/Page column 22 ; US 20060199804 A1
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References
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WO2008/98058 A1, ; Page/Page column 57-58 ; WO 2008/098058 A1
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References
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WO2008/125835 A1, ; Referential example 11 ; WO 2008/125835 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Quality Control
Computational Chemistry Data
- TPSA 38.25
- LogP 1.62
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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