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CS-W001157 4
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1-Naphthalenecarboxylic acid, 7-bromo-

  • CAS No. 51934-39-5

  • Cat. No. CS-0032472
  • Purity≥95%
  • MDL No.MFCD11502678

*For research and further manufacturing use only, not for direct human use.

1-Naphthalenecarboxylic acid, 7-bromo-|CS-0032472

Structure of 51934-39-5

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General Information

  • CAS No. 51934-39-5
  • Cat. No. CS-0032472
  • Purity ≥95%
  • MDL No. MFCD11502678
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇BrO₂
  • Molecular Weight 251.08
  • Synonym(s) 7-Bromonaphthalene-1-carboxylic acid
  • SMILES O=C(C1=C2C=C(Br)C=CC2=CC=C1)O

Description

7-Bromo-1-naphthoic acid is a bench-stable, moisture-tolerant naphthalene derivative featuring a bromine substituent at the 7-position and a carboxylic acid group at the 1-position. This combination enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive scaffolds and polymer architectures.

Application

7-Bromo-1-naphthoic acid serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the naphthalene core for pharmaceutical and materials applications. Its bromine substituent facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid group supports derivatization via esterification, amidation, or decarboxylative transformations. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it ideal for scalable synthesis workflows.

Synthesis

  • Route1
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    • In-stock
      1-Naphthalenecarboxylic acid, 7-bromo-|CS-0032472
      51934-39-5

    References

    • SCHERING CORPORATION Patent: WO2008/100480 A1, 2008 ; Location in patent: Page/Page column 71-72 ; WO 2008/100480 A1
  • Route2

    References

    • Newman,M.S.; Seshadri,S. Journal of Organic Chemistry, 1962 , vol. 27, p. 76 - 78
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    References

    • Newman,M.S.; Seshadri,S. Journal of Organic Chemistry, 1962 , vol. 27, p. 76 - 78

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319-H411
Precautionary Statements : P264-P270-P273-P280-P305+P351+P338-P391-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   3.3005
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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